Materials with empty spaces can be used to trap and store cargo for subsequent delivery at a targeted time and location. Such materials are known as delivery systems. Over the past few years, our group has focused on delivery systems based on porous MOF/COF/MOPs, organic polymers, micelles and vesicles (liposomes). We are currently designing novel stimuli-responsive systems able to release their cargo in response to specific triggers under controllable conditions. Likewise, we are developing novel systems for delivery of therapeutic agents for several diseases, including diabetes, multiple sclerosis, AIDS and stroke.

Representative papers:

Phosphatidylserine-Liposomes Promote Tolerogenic Features on Dendritic Cells in Human Type 1 Diabetes by Apoptotic Mimicry. Frontiers in Inmunology, 2018, DOI: 10.3389/fimmu.2018.00253.

Characterization of ApoJ-reconstituted high-density lipoprotein (rHDL) nanodisc for the potential treatment of cerebral β-amyloidosis. Scientific Reports, 2017, 7:14637, DOI: 10.1038/s41598-017-15215-w. [Full text]

Tuning the endocytosis mechanism of Zr-based MOFs through linker functionalisation. ACS Applied Materials Interfaces 2017, 9, 35516. [Full text]

Validation of liposome-based immunotherapy against autoimmune diseases: therapeutic effect on multiple sclerosis Liposome-based immunotherapy for multiple sclerosis. Nanomedicine: Nanotechnology, Biology and Medicine, 2017, 12, 1234. [Full text]

Microencapsulation with alginate/CaCO3: A strategy for improved phage therapy. Scientific Reports 2017, 7, 41441. [Ful text]

Charge effect of a liposomal delivery system encapsulating simvastatin to treat experimental ischemic stroke in rats. International Journal of Nanomedicine 2016, 11, 3035. [Full text]